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DeCS
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Descritor Inglês:
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Cyclic Nucleotide Phosphodiesterases, Type 2
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Descritor Espanhol:
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Fosfodiesterasas de Nucleótidos Cíclicos Tipo 2
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Descritor Português:
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Nucleotídeo Cíclico Fosfodiesterase do Tipo 2
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Categoria:
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D08.811.277.352.640.150.200
D08.811.277.352.640.155.200
D12.644.360.008.200
D12.644.360.009.200
D12.776.476.008.200
D12.776.476.009.200
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Definição Inglês:
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A cyclic nucleotide phosphodiesterase subfamily that is activated by the binding of CYCLIC GMP to an allosteric domain found on the enzyme. Multiple enzyme variants of this subtype can be produced due to multiple alternative mRNA splicing. The subfamily is expressed in a broad variety of tissues and may play a role in mediating cross-talk between CYCLIC GMP and CYCLIC CMP pathways. Although the type 2 enzymes are classified as 3',5'-cyclic-AMP phosphodiesterases (EC 3.1.4.17), members of this class have additional specificity for CYCLIC-GMP. |
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Nota Histórica Inglês:
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2008(2000)
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Qualificadores Permitidos Inglês:
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Número do Registro:
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52677
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Identificador Único:
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D054678
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Ocorrência na BVS:
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